The Broth & Co Bone Broth Gut Study

Clinical Trial:    

Effect of Broth & Co’s Beef Bone Broth on lower Gastrointestinal Disturbances: The Bone Broth Gut Study                                                                                                                                                                       

KEY Personnel

Chief Investigator: A/Prof Karin Ried, PhD, MSc, GDPH, Cert Integ Med, Director of Research, NIIM

Research Assistants: Nikolaj Travica, BSc(Hons) ntravica@niim.com.au

Junior research assistant: Student

Prof Avni Sali, Director NIIM, asali@niim.com.au 

Effect of Broth & Co’s Beef Bone Broth on lower Gastrointestinal Disturbances: The Bone Broth Gut Study

                                     

Aim

To assess the tolerability and efficacy of a freeze-dried Beef Bone Broth for gastrointestinal disturbances.

 

BACKGROUND

Gastrointestinal problems can manifest as bloating, cramping and pain, constipation, diarrhoea, and conditions such as Inflammatory Bowel Syndrome (IBS), and Crohn’s disease.

 

Bone Broth Gut Study

Executive summary:

 The Bone Broth significantly improved the severity of lower symptoms after 8 weeks, including

constipation, diarrhea, urgency, flatulence, and abdominal pain.

 The Bone Broth significantly improved upper symptoms, including indigestion, heartburn,

regurgitation, and nausea.

 The Bone Broth significantly improved symptoms associated Quality of Life, including emotional

and mental health and wellbeing, sleep, energy, physical functioning, diet and social interactions.

 The Bone Broth significantly improved stool consistency & stool frequency and regularity.

 The Bone Broth significantly improved intestinal permeability or leaky gut in those with elevated

levels at baseline. Specifically, Lactulose and Mannitol Recovery improved by 33%, and

Lactulose/Mannitol Ratio improved by 38%.

 While food triggers had been reported by 83% (25/30) of participants at start of the study,

a large number of participants recovered from the food intolerances,

with more than 80% tolerating again FODMAP containing foods again,

and a third recovered from intolerance to gluten, acidic or spicy foods, dairy, or egg or fried foods,

respectively.

 

Effect of Broth & Co’s Beef Bone Broth on lower Gastrointestinal Disturbances: The Bone Broth

Gut Study - Protocol

Aim

To assess the tolerability and efficacy of a freeze-dried Beef Bone Broth for gastrointestinal disturbances.

Study design

Interventional single-arm pre-post study of 12 weeks duration investigating the tolerability and effectiveness of the Broth & Co Beef Bone Broth on lower gastrointestinal disturbances in Australian adults.

Participants

Inclusion criteria

• Adults with moderate gastrointestinal disturbances of the lower gastrointestinal tract.

Sample size: n=30

Intervention/ Comparison

Month 1: 3-4 week run-in phase = control phase

Month 2+3: 2 x 5g Beef Bone Broth plain/ day (2x 1 tsp from 100g pouch) mixed in warm water, or mixed in a smoothie.

References

 

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4.         Lacy BE, Patel NK. Rome Criteria and a Diagnostic Approach to Irritable Bowel Syndrome. Journal of clinical medicine 2017;6:99.

5.         Mishra A, Makharia GK. Techniques of functional and motility test: how to perform and interpret intestinal permeability. Journal of neurogastroenterology and motility 2012;18:443.

6.         Johnston SD, Smye M, Watson R. Intestinal permeability tests in coeliac disease. Clinical laboratory 2001;47:143-50.

7.         Juby L, Rothwell J, Axon A. Lactulose/mannitol test: an ideal screen for celiac disease. Gastroenterology 1989;96:79-85.

8.         Camilleri M, Nadeau A, Lamsam J, Linker Nord S, Ryks M, Burton D, et al. Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion. Neurogastroenterology & Motility 2010;22:e15-e26.

9.         Whorwell P, McCallum M, Creed F, Roberts C. Non-colonic features of irritable bowel syndrome. Gut 1986;27:37-40.

10.       Agrawal A, Whorwell P. BMJ learning: irritable bowel syndrome: diagnosis and management. BMJ: British Medical Journal 2006;332:280.